Cryptic crossword clue
Change popular recreational drug for opiate 8

The most common and most likely answer to this crossword clue is the 8 letter word MORPHINE

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The cryptic/wordplay part
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This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
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What does MORPHINE mean?

MORPHINE noun
  1. A crystalline alkaloid (7,8-didehydro-4,5-epoxy-17-methyl-morphinan-3,6-diol), extracted from opium, the salts of which are soluble in water and are used as analgesics, anaesthetics and sedatives; it is one of a group of morphine alkaloids.

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