Cryptic crossword clue
Changed, fifty pestilent houses 9

The most common and most likely answer to this crossword clue is the 9 letter word INFLECTED

I've seen this crossword clue in The Guardian
I
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Buddy explains!

The straight part
We know that "Changed" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case changed = inflected.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does INFLECTED mean?

INFLECTED verb
  1. To cause to curve inwards.
  2. To change the tone or pitch of the voice when speaking or singing.
  3. (grammar) To vary the form of a word to express tense, gender, number, mood, etc.
  4. (grammar, of a word) To be varied in the form to express tense, gender, number, mood, etc.
  5. To influence in style.
INFLECTED adjective
  1. Deviating from a straight line.
  2. (grammar) Changed in form to reflect function (referring to a word).
  3. Having inflected word forms; fusional.
  4. Bent or curved inward or downward

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