Cryptic crossword clue
Changes brought about 100 enlarged vessels 7

The most common and most likely answer to this crossword clue is the 7 letter word VARICES

V
A
R
I
C
E
S

Buddy explains!

The straight part
We know that "enlarged vessels" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case enlarged vessels = varices.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does VARICES mean?

VARICES noun
  1. A varicose, i.e. swollen and knotted, vein
  2. In mollusks, a particular ridge on the shell, corresponding to a former position of the aperture.

Latest crossword clues with full explanations