Cryptic crossword clue
Changing mind, supporter in US city sheds weight 12

The most common and most likely answer to this crossword clue is the 12 letter word BRAINWASHING

I've seen this crossword clue in Financial Times
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Buddy explains!

The straight part
We know that "Changing mind" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case changing mind = brainwashing.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does BRAINWASHING mean?

BRAINWASHING noun
  1. A form of indoctrination that forces people to abandon their beliefs in favour of another set of beliefs by conditioning through various forms of pressure or torture
BRAINWASHING verb
  1. To affect one's mind by using extreme mental pressure or any other mind-affecting process. (e.g. hypnosis)
  2. To take from an electronically controlled machine its stored-up information; to erase a computer's programming. (1960)

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