Cryptic crossword clue
Changing times in the saga about human knowledge 9

The most common and most likely answer to this crossword clue is the 9 letter word EPISTEMIC

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Buddy explains!

The straight part
We know that "about human knowledge" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case about human knowledge = epistemic.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does EPISTEMIC mean?

EPISTEMIC adjective
  1. Of or relating to knowledge or cognition; cognitive.
  2. Of or relating to the theory of knowledge (epistemology).

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