Cryptic crossword clue
Chaotic disintegration can become most confusing 14

The most common and most likely answer to this crossword clue is the 14 letter word DISORIENTATING

I've seen this crossword clue in The Daily Telegraph
D
I
S
O
R
I
E
N
T
A
T
I
N
G

Buddy explains!

The straight part
We know that "most confusing" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case most confusing = disorientating.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does DISORIENTATING mean?

DISORIENTATING verb
  1. To cause to lose orientation or direction.
  2. To confuse or befuddle.

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