The most common and most likely answer to this crossword clue is the 4 letter word FRAU
I've seen this crossword clue in The Times
F
R
A
U
More clues leading to the result FRAU
- Hamburger off the shelf?
- German lady reveals deception after loss of diamonds
- Charlatan tailed 1 down in Berlin
- Hamburger perhaps almost a deception
- Almost all cheating to get European title
- Married woman’s cheating husband finally kicked out
- Mostly cheating wife
- Dutch in Germany no closer to crime
- German partner in crime duke knocked out
- Wife‘s endless cheating
Buddy explains!

The straight part
We know that "1 down in Berlin" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case 1 down in berlin = frau.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does FRAU mean?
FRAU noun- A woman, especially a German woman.