The most common and most likely answer to this crossword clue is the 8 letter word CEREBRUM
I've seen this crossword clue in The Times
C
E
R
E
B
R
U
M
More clues leading to the result CEREBRUM
- Charlie regularly decries Birmingham thinker
- Cold beer produced strange thoughts here
- Church concerned with familiar city in part of the 10
- Spirit after cold beer addled part of brain
- The mind of a sincere Brummie
- Section of upper storey park over east Birmingham
- One thinks about industrial city familiarly after church
Buddy explains!
The straight part
We know that "thinker" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case thinker = cerebrum.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does CEREBRUM mean?
CEREBRUM noun- The upper part of the brain, which is divided into the two cerebral hemispheres. In humans it is the largest part of the brain and is the seat of motor and sensory functions, and the higher mental functions such as consciousness, thought, reason, emotion, and memory.