Cryptic crossword clue
Chemical making leather without using hydrogen 5

The most common and most likely answer to this crossword clue is the 5 letter word OXIDE

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Buddy explains!

The straight part
We know that "Chemical" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case chemical = oxide.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does OXIDE mean?

OXIDE noun
  1. A binary chemical compound of oxygen with another chemical element.

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