The most common and most likely answer to this crossword clue is the 4 letter word ALAR
A
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A
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More clues leading to the result ALAR
Buddy explains!

The straight part
We know that "Chemical once used by e.g. 20" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case chemical once used by e.g. 20 = alar.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does ALAR mean?
ALAR adjective- Of or relating to the armpit; axillary.
- Having, resembling, or composed of wings or alae.