The most common and most likely answer to this crossword clue is the 6 letter word KETONE
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The straight part
We know that "Chemical’" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case chemical’ = ketone.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does KETONE mean?
KETONE noun- A homologous series of organic molecules whose functional group is an oxygen atom joined to a carbon atom—by a double bond—in a carbon-hydrogen based molecule.