The most common and most likely answer to this crossword clue is the 8 letter word CAKEHOLE
I've seen this crossword clue in The Guardian
C
A
K
E
H
O
L
E
More clues leading to the result CAKEHOLE
Buddy explains!
The straight part
We know that "Choke with ale going the wrong way down this?" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case choke with ale going the wrong way down this? = cakehole.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does CAKEHOLE mean?
CAKEHOLE noun- The mouth.