Cryptic crossword clue
Choking river endlessly, rubbish ahead gets regulator in mood 9

The most common and most likely answer to this crossword clue is the 9 letter word SEROTONIN

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Buddy explains!

The straight part
We know that "regulator in mood" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case regulator in mood = serotonin.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does SEROTONIN mean?

SEROTONIN noun
  1. An indoleamine neurotransmitter, 5-hydroxytryptamine, that is involved in depression, appetite, etc., and is crucial in maintaining a sense of well-being, security, etc.

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