Cryptic crossword clue
Choose one mother — the best! 6

The most common and most likely answer to this crossword clue is the 6 letter word OPTIMA

I've seen this crossword clue in The Guardian
O
P
T
I
M
A

Buddy explains!

The straight part
We know that "the best" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case the best = optima.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does OPTIMA mean?

OPTIMA noun
  1. The best or most favorable condition, or the greatest amount or degree possible under specific sets of comparable circumstances.

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