Cryptic crossword clue
Chronic complainer's great cry of pain 6

The most common and most likely answer to this crossword clue is the 6 letter word GROUCH

G
R
O
U
C
H

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The straight part
We know that "Chronic complainer" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case chronic complainer = grouch.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does GROUCH mean?

GROUCH noun
  1. A complaint, a grumble, a fit of ill-humor.
  2. One who is grumpy or irritable.
GROUCH verb
  1. To be grumpy or irritable; to complain.

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