Cryptic crossword clue
City and I separately probing blue material cheesy stuff

The most common and most likely answer to this crossword clue is the 8 letter word PECORINO

I've seen this crossword clue in The Guardian
P
E
C
O
R
I
N
O


Buddy explains!

The straight part
We know that "cheesy stuff" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case cheesy stuff = pecorino.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does PECORINO mean?

PECORINO noun
  1. Any of a family of Italian cheeses made from ewe's milk.

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