The most common and most likely answer to this crossword clue is the 4 letter word PISA
I've seen this crossword clue in The Times
P
I
S
A
More clues leading to the result PISA
- City is in Pennsylvania? Yes and no
- European city is area under pressure
- Most famous listed building here?
- A drink knocked up in Tuscan city
- First to propose a way to save Italian city
- A little drink knocked back in Italian city
- Reportedly goes with American city
- Sightseers here perhaps inclined to knock back a little drink
- Old man lives in Italian city
- City whose fame is based on dodgy foundations
Buddy explains!

The straight part
We know that "City" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case city = pisa.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.