The most common and most likely answer to this crossword clue is the 6 letter word BOSTON
I've seen this crossword clue in The Guardian
B
O
S
T
O
N
More clues leading to the result BOSTON
- East Anglian town that’s ‘stumped’
- Particle split by head of thermodynamics in city abroad
- City physicist finally splitting subatomic particle
- US city street in favour
- Mass location maybe where holy person is garlanded with blessing
- US city street in financially favourable situation
- American city less British, in short? The reverse
- Mass housing this type of terrier‘s found
- City street learner reversed around
- Good man invested in good thing in US city
Buddy explains!

The straight part
We know that "City/City" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case city/city = boston.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.