Cryptic crossword clue
City types liable to lose their aspiration 8

The most common and most likely answer to this crossword clue is the 8 letter word COCKNEYS

I've seen this crossword clue in The Daily Telegraph
C
O
C
K
N
E
Y
S

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The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does COCKNEYS mean?

COCKNEYS noun
  1. A native or inhabitant of parts of the East End of London
  2. The accent and speech mannerisms of these people
  3. An effeminate person; a spoilt child.

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