Cryptic crossword clue
Clap hands initially on ogre, or a deviant

The most common and most likely answer to this crossword clue is the 10 letter word GONORRHOEA

I've seen this crossword clue in The Guardian
G
O
N
O
R
R
H
O
E
A

Buddy explains!

The straight part
We know that "Clap" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case clap = gonorrhoea.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does GONORRHOEA mean?

GONORRHOEA noun
  1. An STD caused by a species of bacteria (the gonococcus) that affects the mucous membrane of the genital and urinary tracts.

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