Cryptic crossword clue
Clapton initially greeting sound of guitar effect as insignificant nuisance on the end of a lead 9

The most common and most likely answer to this crossword clue is the 9 letter word CHIHUAHUA

C
H
I
H
U
A
H
U
A


Buddy explains!

The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does CHIHUAHUA mean?

CHIHUAHUA noun
  1. The smallest breed of dog in the world, originating in Mexico and having large erect ears.

Latest crossword clues with full explanations