Cryptic crossword clue
Classes are set up after fellow ultimately lost 6

The most common and most likely answer to this crossword clue is the 6 letter word GENERA

I've seen this crossword clue in The Sunday Telegraph
G
E
N
E
R
A


Buddy explains!

The straight part
We know that "Classes" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case classes = genera.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does GENERA mean?

GENERA noun
  1. A rank in the classification of organisms, below family and above species; a taxon at that rank.
  2. A group with common attributes.
  3. A natural number representing any of several related measures of the complexity of a given manifold or graph.
  4. Within a definition, a broader category of the defined concept.

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