Cryptic crossword clue
Cleanse and refine superfamily short of males 6

The most common and most likely answer to this crossword clue is the 6 letter word PURIFY

I've seen this crossword clue in Financial Times
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Buddy explains!

The straight part
We know that "Cleanse" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case cleanse = purify.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does PURIFY mean?

PURIFY verb
  1. To cleanse, or rid of impurities.
  2. To free from guilt or sin.
  3. To become pure.

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