Cryptic crossword clue
Clot in the European capital repeatedly missing last coach 8

The most common and most likely answer to this crossword clue is the 8 letter word THROMBUS

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Buddy explains!

The straight part
We know that "Clot" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case clot = thrombus.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does THROMBUS mean?

THROMBUS noun
  1. A blood clot formed from platelets and other elements that forms in a blood vessel in a living organism, and causes thrombosis or obstruction of the vessel at its point of formation or travel to other areas of the body.

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