Cryptic crossword clue
Cockney sulks when opening number’s ending 6

The most common and most likely answer to this crossword clue is the 6 letter word SUFFIX

I've seen this crossword clue in The Times
S
U
F
F
I
X

Buddy explains!

The straight part
We know that "ending" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case ending = suffix.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does SUFFIX mean?

SUFFIX noun
  1. (grammar) A morpheme added at the end of a word to modify the word's meaning.
  2. A subscript.
  3. A final segment of a string of characters.
SUFFIX verb
  1. To append (something) to the end of something else.

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