The most common and most likely answer to this crossword clue is the 4 letter word MOJO
M
O
J
O
More clues leading to the result MOJO
- Magic doctor US soldier heard
- Wizardry of a long-distance runner on run not last!
- Jack goes in low — it’s magic
- Charm shown by two little women
- Magic cocktail lacking vermouth
- Jack, coming in low, exudes charm
- That thing omitted from a Cuban cocktail — it gives magical power
- Chant in an upside-down position while drinking juice to make magic
- Cocktail without vermouth, it’s magic!
- Cocktail eschewing vermouth is magic
Buddy explains!

The straight part
We know that "magic" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case magic = mojo.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does MOJO mean?
MOJO noun- A magic charm or spell.
- Supernatural skill or luck.
- Personal magnetism; charm.
- Sex appeal; sex drive.
- Illegal drugs.
- (usually with "wire") A telecopier; a fax machine.