The most common and most likely answer to this crossword clue is the 6 letter word ADDERS
I've seen this crossword clue in The Guardian
A
D
D
E
R
S
More clues leading to the result ADDERS
- Dreads writhing snakes
- Runs off with large sum? We do
- Venomous types putting two and two together?
- 23 Producers of serpentine dreads?
- Cold-blooded calculators?
- Board game, left out, provides both definition and solution
- Dreads lousy summers?
- Poisonous types more miserable first to last
- Reptiles they don’t take away
- Tot unfortunately worse before getting right herbal remedy
Buddy explains!

The straight part
We know that "Cold-blooded calculators" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case cold-blooded calculators = adders.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does ADDERS mean?
ADDERS noun- Any snake.
- A name loosely applied to various snakes more or less resembling the viper; a viper.
- Someone who or something which performs arithmetic addition; a machine for adding numbers.
- An electronic device that adds voltages, currents or frequencies.
- Something which adds or increases.