The most common and most likely answer to this crossword clue is the 5 letter word CRAMP
I've seen this crossword clue in The Times
C
R
A
M
P
More clues leading to the result CRAMP
- Pain from running, perhaps — affected after covering run
- Restrict stuff on page
- Painful experience when river floods holiday site?
- Cold, something inclined to give one pain
- Aid for climber getting rid of leg pain
- Brandy knocked back by first of patients in pain
- Cold climb posing problem for athlete?
- Stuff given to priest for pain?
- Hamper stuff for Jock must include opener for Merlot
- Pain of male in very poor surroundings
Buddy explains!

The straight part
We know that "to give one pain" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case to give one pain = cramp.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does CRAMP mean?
CRAMP noun- A painful contraction of a muscle which cannot be controlled.
- That which confines or contracts; a restraint; a shackle; a hindrance.
- A clamp for carpentry or masonry.
- A piece of wood having a curve corresponding to that of the upper part of the instep, on which the upper leather of a boot is stretched to give it the requisite shape.
- (of a muscle) To contract painfully and uncontrollably.
- To affect with cramps or spasms.
- To prohibit movement or expression of.
- To restrain to a specific physical position, as if with a cramp.
- To fasten or hold with, or as if with, a cramp iron.
- (by extension) To bind together; to unite.
- To form on a cramp.
- Cramped; narrow