The most common and most likely answer to this crossword clue is the 6 letter word ADAMIC
I've seen this crossword clue in The Guardian
A
D
A
M
I
C
More clues leading to the result ADAMIC
Buddy explains!

The straight part
We know that "in the nude" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case in the nude = adamic.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.