The most common and most likely answer to this crossword clue is the 6 letter word GNOMIC
I've seen this crossword clue in The Daily Telegraph
G
N
O
M
I
C
More clues leading to the result GNOMIC
- Coming out – like our proprietor?
- First day smoke rings rising, mysterious and seemingly wise
- Setter’s in deceitful activity, finally offering up cryptic
- Coming fashioned like a pithy saying
- Try to bag new sound device that’s hard to get
- Coming out is difficult to understand
- Coming out with pithy remark
- Coming out with pithy sayings
- Coming out with pithy saying
- Coming off as enigmatic
Buddy explains!

The straight part
We know that "with pithy remark" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case with pithy remark = gnomic.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does GNOMIC mean?
GNOMIC adjective- Of, or relating to gnomes (sententious sayings).
- (of a saying or aphorism) Mysterious and often incomprehensible yet seemingly wise.
- (grammar) Expressing general truths or aphorisms.