Cryptic crossword clue
Comment is twisted and mean 8

The most common and most likely answer to this crossword clue is the 8 letter word SIDENOTE

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The straight part
We know that "Comment" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case comment = sidenote.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does SIDENOTE mean?

SIDENOTE noun
  1. A note or notation made in a side margin.
  2. A minor related mention, made as an aside, or afterthought.

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