The most common and most likely answer to this crossword clue is the 5 letter word CRAPS
I've seen this crossword clue in Independent
C
R
A
P
S
More clues leading to the result CRAPS
Buddy explains!

The straight part
We know that "game" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case game = craps.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does CRAPS mean?
CRAPS noun- A game of gambling, or chance, where the players throw dice to make scores and avoid crap.
- The husk of grain; chaff.
- (mildly) Something worthless or of poor quality; junk.
- (mildly) Nonsense; something untrue.
- (mildly) Faeces/feces.
- (mildly) An act of defecation.
- A losing throw of 2, 3, or 12 in craps.
- To defecate.
- To defecate in or on (clothing etc.).
- To bullshit.