Cryptic crossword clue
Completely exhausted, having lost essential part of thyroid gland

The most common and most likely answer to this crossword clue is the 8 letter word PROSTATE

I've seen this crossword clue in The Guardian
P
R
O
S
T
A
T
E


Buddy explains!

The straight part
We know that "gland" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case gland = prostate.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does PROSTATE mean?

PROSTATE noun
  1. The prostate gland.
PROSTATE adjective
  1. Of or relating to the prostate gland.
PROSTATE adjective
  1. Favoring the government, or favoring the government of a state as opposed to a federal government.

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