Cryptic crossword clue
Component of cell made of metal, mostly, with part hiding hole 10

The most common and most likely answer to this crossword clue is the 10 letter word CHROMOSOME

I've seen this crossword clue in Independent
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What does CHROMOSOME mean?

CHROMOSOME noun
  1. A linear arrangement of condensed DNA and associated proteins (such as chaperone proteins) which contains the genetic material (genome) of an organism.

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