Cryptic crossword clue
Concentrate less with endless cacophony on instrument

The most common and most likely answer to this crossword clue is the 6 letter word DILUTE

I've seen this crossword clue in The Guardian
D
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The straight part
We know that "Concentrate less" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case concentrate less = dilute.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does DILUTE mean?

DILUTE noun
  1. An animal having a lighter-coloured coat than is usual.
DILUTE verb
  1. To make thinner by adding solvent to a solution, especially by adding water.
  2. To weaken, especially by adding a foreign substance.
  3. To cause the value of individual shares or the stake of a shareholder to decrease by increasing the total number of shares.
  4. To become attenuated, thin, or weak.
DILUTE adjective
  1. Having a low concentration.
  2. Weak; reduced in strength by dilution; diluted.
  3. Of an animal: having a lighter-coloured coat than is usual.

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