Cryptic crossword clue
Concern about being in charge in isolation 10

The most common and most likely answer to this crossword clue is the 10 letter word SOLICITUDE

I've seen this crossword clue in The Daily Telegraph
S
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The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does SOLICITUDE mean?

SOLICITUDE noun
  1. The state of being solicitous; uneasiness of mind occasioned by fear of evil or desire for good; anxiety.
  2. Special or pronounced concern or attention.
  3. A cause of anxiety or concern.

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