Cryptic crossword clue
Confirmed spineless creature lacks courage and fibre essentially 10

The most common and most likely answer to this crossword clue is the 10 letter word INVETERATE

I've seen this crossword clue in Independent
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Buddy explains!

The straight part
We know that "Confirmed" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case confirmed = inveterate.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does INVETERATE mean?

INVETERATE verb
  1. To fix and settle after a long time; to entrench.
INVETERATE adjective
  1. Firmly established from having been around for a long time; of long standing
  2. (of a person) Having had a habit for a long time
  3. Malignant; virulent; spiteful.

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