Cryptic crossword clue
Confuses first letter to be the last above 6

The most common and most likely answer to this crossword clue is the 6 letter word ADDLES

A
D
D
L
E
S

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The straight part
We know that "Confuses" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case confuses = addles.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does ADDLES mean?

ADDLES verb
  1. (provincial) To earn, earn by labor; earn money or one's living.
  2. (provincial) To thrive or grow; to ripen.
ADDLES noun
  1. A foolish or dull-witted fellow.
ADDLES noun
  1. Liquid filth; mire.
  2. (provincial) Lees; dregs.
ADDLES verb
  1. To make addle; to grow addle; to muddle
  2. To cause fertilised eggs to lose viability, by killing the developing embryo within through shaking, piercing, freezing or oiling, without breaking the shell.

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