The most common and most likely answer to this crossword clue is the 6 letter word INFECT
I
N
F
E
C
T
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The straight part
We know that "Contaminate" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case contaminate = infect.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does INFECT mean?
INFECT verb- To bring into contact with a substance that causes illness (a pathogen).
- To make somebody enthusiastic about one's own passion.
- Infected.