Cryptic crossword clue
Cooked penne, ate 2/3rd — necessitated hospital entry to have a drug 8

The most common and most likely answer to this crossword clue is the 8 letter word NEPENTHE

N
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The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does NEPENTHE mean?

NEPENTHE noun
  1. A drug mentioned in Homer's Odyssey (c. 8th century B.C.E.) as bringing relief from anxiety or grief; hence, any drug or substance seen as bringing welcome forgetfulness or relief.
  2. A Southeast Asian carnivorous plant of the genus Nepenthes; a monkey cup or tropical pitcher plant.

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