Cryptic crossword clue
Cops lose suspect in den of vice

The most common and most likely answer to this crossword clue is the 8 letter word CESSPOOL

I've seen this crossword clue in Independent
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Buddy explains!

The straight part
We know that "den of vice" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case den of vice = cesspool.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does CESSPOOL mean?

CESSPOOL noun
  1. An underground pit where sewage is held.
  2. (by extension) A filthy place.

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