The most common and most likely answer to this crossword clue is the 10 letter word EXTREMISTS
I've seen this crossword clue in The Guardian
E
X
T
R
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More clues leading to the result EXTREMISTS
Buddy explains!

The straight part
We know that "fanatics" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case fanatics = extremists.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does EXTREMISTS mean?
EXTREMISTS noun- A person who holds extreme views, especially one who advocates such views; a radical or fanatic.