The most common and most likely answer to this crossword clue is the 10 letter word HEARTBREAK
I've seen this crossword clue in Independent
H
E
A
R
T
B
R
E
A
K
More clues leading to the result HEARTBREAK
- Pick up wood with odd bits of bark in desolation
- Anguish of ambassador over holiday tour of galleries?
- Trauma? Pay attention to temperature and rest
- Hater – of great sorrow?
- Courage to overcome grief
- Sorrow thus seen in hater?
- Great sadness to learn about a king catching nasty disease
- Take her bra off? It’s extremely distressing
Buddy explains!
The straight part
We know that "grief" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case grief = heartbreak.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does HEARTBREAK mean?
HEARTBREAK noun- Overwhelming mental anguish or grief, especially that caused by loss or disappointment