Cryptic crossword clue
Crack up back of gluteal area, you disgust me! 5

The most common and most likely answer to this crossword clue is the 5 letter word LAUGH

I've seen this crossword clue in The Guardian
L
A
U
G
H


Buddy explains!

The straight part
We know that "Crack up" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case crack up = laugh.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does LAUGH mean?

LAUGH noun
  1. An expression of mirth particular to the human species; the sound heard in laughing; laughter.
  2. Something that provokes mirth or scorn.
  3. A fun person.
LAUGH verb
  1. To show mirth, satisfaction, or derision, by peculiar movement of the muscles of the face, particularly of the mouth, causing a lighting up of the face and eyes, and usually accompanied by the emission of explosive or chuckling sounds from the chest and throat; to indulge in laughter.
  2. To be or appear cheerful, pleasant, mirthful, lively, or brilliant; to sparkle; to sport.
  3. (followed by "at") To make an object of laughter or ridicule; to make fun of; to deride; to mock.
  4. To affect or influence by means of laughter or ridicule.
  5. To express by, or utter with, laughter.

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