The most common and most likely answer to this crossword clue is the 5 letter word MANIC
I've seen this crossword clue in The Guardian
M
A
N
I
C
More clues leading to the result MANIC
- Crazy bloke in charge
- Hyperactive person in charge
- Crazed genius’s heart controlled by tablet, perhaps?
- Chap in charge is run off his feet
- Feverish fellow in charge
- Frantic bloke with ultimate responsibility?
- Most of digital enhancement is crazy
- Joe’s flaky ice cream, whipped up
- Niece oddly neglected after servant becomes deranged
- Frenzied comic in amusing clothes, making comeback
Buddy explains!

The straight part
We know that "Crazed" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case crazed = manic.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does MANIC mean?
MANIC adjective- Of or pertaining to someone who exhibits mania or craziness; wicked.
- Suffering from mania, the state of an abnormally elevated or irritable mood, arousal, and/or energy levels.