Cryptic crossword clue
Crazy leader is nut to be made ineffective 11

The most common and most likely answer to this crossword clue is the 11 letter word NEUTRALISED

I've seen this crossword clue in The Daily Telegraph
N
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Buddy explains!

The straight part
We know that "made ineffective" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case made ineffective = neutralised.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does NEUTRALISED mean?

NEUTRALISED verb
  1. To make even, inactive or ineffective.
  2. To make (a territory, etc.) politically neutral.
  3. To make (an acidic or alkaline substance) chemically neutral.
  4. To kill.

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