The most common and most likely answer to this crossword clue is the 10 letter word FRANGIPANE
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More clues leading to the result FRANGIPANE
Buddy explains!

The straight part
We know that "Cream" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case cream = frangipane.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does FRANGIPANE mean?
FRANGIPANE noun- A cream made from ground almonds used in confectionery
- A pastry filled with this cream
- Any of several tropical American trees, of the genus Plumeria, having fragrant, showy, funnel-shaped flowers of a wide range of colours from creamy to red.
- A perfume originally obtained from these flowers