The most common and most likely answer to this crossword clue is the 4 plus 2 letter word MAKE UP
I've seen this crossword clue in The Daily Telegraph
M
A
K
E
U
P
Buddy explains!
The straight part
We know that "Create/settle differences" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case create/settle differences = make up.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does MAKE UP mean?
MAKE UP adjective- Made-up, false, imaginary, fabricated.
- Of or relating to a reconciliation.
- An item's composition.
- Cosmetics; colorants and other substances applied to the skin to alter its appearance.
- Replacement; material used to make up for the amount that has been used up.
- A test given to students allowing them to repeat failed material.