Cryptic crossword clue
Creature found in beer vet brewed — one with a spine! 10

The most common and most likely answer to this crossword clue is the 10 letter word VERTEBRATE

I've seen this crossword clue in The Guardian
V
E
R
T
E
B
R
A
T
E

Buddy explains!

The straight part
We know that "one with a spine" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case one with a spine = vertebrate.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does VERTEBRATE mean?

VERTEBRATE noun
  1. An animal having a backbone.
VERTEBRATE adjective
  1. Having a backbone.

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