Cryptic crossword clue
Cries outside emergency room, calms down 6

The most common and most likely answer to this crossword clue is the 6 letter word SOBERS

S
O
B
E
R
S

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The straight part
We know that "calms down" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case calms down = sobers.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does SOBERS mean?

SOBERS verb
  1. (often with up) To make or become sober.
  2. (often with up) To overcome or lose a state of intoxication.
  3. To moderate one's feelings

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